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KMID : 1134120220250010025
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Journal of Breast Cancer
2022 Volume.25 No. 1 p.25 ~ p.36
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The Usefulness of Ultrasound Surveillance for Axillary Recurrence in Women With Personal History of Breast Cancer
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Shin Sung-Ui
Chang Jung-Min
Park Ji-Won
Lee Han-Byoel
Han Won-Shik
Moon Woo-Kyung
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Abstract
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Purpose: To evaluate the axillary recurrence rate and usefulness of axillary ultrasound (AUS) during supplementary whole-breast ultrasound (US) screening in women with a personal history of breast cancer (PHBC).
Methods: A retrospective database search identified consecutive asymptomatic women who underwent postoperative supplemental whole-breast US screening, including that of the bilateral axillae, after negative findings on mammography between January and June 2017. Using the pathologic data or at least 1-year follow-up data as reference standards, the axillary recurrence rate, cancer detection rate (CDR), interval axillary recurrence rate per 1,000 screenings, sensitivity, specificity, and abnormal interpretation rate (AIR) were estimated.
Results: From the data of 4,430 women (mean age, 55.0 ± 10.1 years) analyzed in this study, there were five axillary recurrence cases (1.1/1,000) in the median follow-up period of 57.2 months. AUS showed a CDR of 0.2 (1/4,430; 95% confidence interval [CI], 0.01?1.3) and an interval axillary recurrence rate of 0.9 (4/4,402; 95% CI, 0.2?2.3) per 1,000 examinations. The sensitivity and specificity were 20.0% (1/5; 95% CI, 0.5?71.6), and 99.4% (4,398/4,425; 95% CI, 99.1?99.6), respectively, while the AIR was 0.6% (28/4,430; 95% CI, 0.4?0.9%).
Conclusion: In asymptomatic women with a PHBC and negative findings on mammography, axillary recurrence after breast cancer and axillary treatment was uncommon, and the supplemental AUS screening yielded 0.2 cancers per 1,000 examinations.
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KEYWORD
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Breast Neoplasms, Mass Screening, Population Surveillance, Recurrence, Ultrasonography
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